Why the study?
The lack of defined diagnostic criteria makes acute myocarditis dependent on clinical suspicion, prompting an evaluation of current trends in demographics, clinical manifestations, treatments, and outcomes in children hospitalized in the United States.
What are the current trends in demographics, treatments, and outcomes for children hospitalized with acute myocarditis in the United States?
Population
1199 patients 21 years or younger hospitalized with acute myocarditis in the United States
Design
Retrospective database study
Key result
Among 1199 children hospitalized with acute myocarditis, overall hospital mortality was 2.3%, and administration of IVIG was independently associated with reduced mortality (p=0.01).
Authors
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IVIG may warrant consideration in pediatric acute myocarditis; reinforces consensus but leaves open causality pending RCTs.
Cohort (n=1,199)
Yes
What are the current trends in demographics, treatments, and outcomes for children hospitalized with acute myocarditis in the United States?
p-value: p=0.01
In children hospitalized with acute myocarditis, overall mortality is low (2.3%) despite high morbidity, and IVIG administration is independently associated with reduced mortality.
Singh et al. (2026) conducted a cohort in Acute myocarditis (n=1,199). IVIG was evaluated on Hospital mortality (p=0.01). Among 1199 children hospitalized with acute myocarditis, overall hospital mortality was 2.3%, and administration of IVIG was independently associated with reduced mortality (p=0.01).