Hypoxic-inflammatory preconditioning endows BMSC-derived appoptotic extracellular vesicles with potent efficacy against IVDD via cell activation and mitochondrial homeostasis regulation
Experiment assesses enhanced efficacy of apoptotic extracellular vesicles in IVDD, indicating implications for tissue regeneration therapies.
Key Points
This research aims to investigate the therapeutic efficacy of apoptotic extracellular vesicles derived from MSCs under hypoxic-inflammatory conditions in IVDD.
Cultured mesenchymal stem cells under hypoxic and hypoxic-inflammatory conditions.
Extracted apoptotic extracellular vesicles (I-ApoEVs) for assessment.
Evaluated the viability of nucleus pulposus cells and mitochondrial function post-treatment.
I-ApoEVs significantly enhance the viability of nucleus pulposus cells compared to control.
Improved mitochondrial function was observed with I-ApoEVs after treatment.
Hypoxic-inflammatory pretreatment led to better regulatory effects on mitochondrial homeostasis.