What does this research mean for the field?

In cases of Bothrops bilineatus snakebite, standard polyvalent antibothropic antivenom (SAB) may fail, while antivenom directed against Lachesis muta (SABL) can provide effective treatment. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

Examine a rare case of Bothrops bilineatus snakebite with therapeutic failure to standard antivenom and response to an alternative treatment.

March 17, 2026The Brazilian Journal of Infectious DiseasesOpen Access

Atypical Case of Bothrops Bilineatus Snakebite: Therapeutic Failure to Antibothropic Antivenom and Exclusive Response to Antibothropic-Lachetic Antivenom

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Authors

TNThaynara Franciele NevesUniversidade Federal de Roraima JNJânio J. M. NattrodtUniversidade Estadual de Roraima LGLuis Enrique Bermejo GalanUniversidad Autónoma de Nuevo León

Discussion

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Implication

Case report uncovers therapeutic failure of common antivenom in Indigenous patient, suggesting need for alternative treatments.

Key Points

Examine a rare case of Bothrops bilineatus snakebite with therapeutic failure to standard antivenom and response to an alternative treatment.
Descriptive case report following a 23-year-old Indigenous male patient bitten by Bothrops bilineatus.
Treatment involved initial administration of polyvalent antibothropic antivenom, followed by an alternative antivenom after failure of the standard treatment.
Laboratory monitoring and clinical evaluations were conducted throughout the treatment process.
Patient exhibited severe local inflammation, gingival bleeding, and prolonged coagulation times despite receiving 18 vials of standard antivenom.
Alternative antivenom (SABL) was administered after therapeutic failure, resulting in global and lasting clinical improvement.
The case indicated potential variability in the venom composition of Bothrops bilineatus, affecting antivenom efficacy.

Cite This Study

Neves et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef52deb47d591b8c5515 https://doi.org/10.1016/j.bjid.2026.105565

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Atypical Case of Bothrops Bilineatus Snakebite: Therapeutic Failure to Antibothropic Antivenom and Exclusive Response to Antibothropic-Lachetic Antivenom

Discussion

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Implication

Key Points

Cite This Study

Atypical Case of Bothrops Bilineatus Snakebite: Therapeutic Failure to Antibothropic Antivenom and Exclusive Response to Antibothropic-Lachetic Antivenom

Discussion

Member takes

Implication

Key Points

Cite This Study

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