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March 17, 2026The Brazilian Journal of Infectious DiseasesOpen Access

Infections Caused by NDM- And Ndm+kpc-Producing Enterobacterales: Epidemiological Profile in a University Hospital

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Authors

RSRafael Amoroso SantosNANathália AbichabkiNGNayara Maria Garcia

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Overview

Epidemiological profile of NDM and NDM+KPC infections reveals significant clinical implications.

Key Points

  • The study aims to characterize the epidemiology of infections caused by NDM- and NDM+KPC-producing Enterobacterales.
  • Analyzed bacterial isolates from clinical specimens like urine, tracheal aspirates, blood, and surgical wounds
  • Utilized immunochromatographic assay for detecting NDM and KPC carbapenemases
  • Applied MALDI-TOF for bacterial identification
  • Collected clinical data through chart review
  • Identified 36 NDM-producing isolates and 9 NDM+KPC co-producing isolates
  • Most isolates originated from urine samples (35%) and tracheal aspirates (20%)
  • 33 patients affected, median age 63 years with a 42% mortality rate
  • Immunosuppressed patients accounted for 15.2% of cases

Cite This Study

Santos et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef6ddeb47d591b8c5718https://doi.org/10.1016/j.bjid.2026.104685
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COMPARISON OF THE PROFILE OF HAIS CAUSED BY KLEBSIELLA SPP. AND OTHER ENTEROBACTERIA PRODUCING THE NEW DELHI METALLO-Β-LACTAMASE ENZYME2026
  2. 2P-1067. Navigating the Dual Threat: Clinical Outcomes in Patients with KPC and NDM Co-producing Enterobacterales Infections2026
  3. 3Clinical and Molecular Characteristics of Patients with Bloodstream Infections Caused by KPC and NDM Co-Producing Carbapenem-Resistant Klebsiella pneumoniae2024 · 25 citations
  4. 4Evaluation of the in vitro susceptibility of clinical isolates of NDM-producing Klebsiella pneumoniae to new antibiotics included in a treatment regimen for infections2024 · 9 citations
  5. 5Emergence and Dissemination of NDM+OXA-48-like Co-Producing Klebsiella pneumoniae in a Regional Healthcare Network: Seven-Year Surveillance from Latium, Italy2026