Emergence and Dissemination of NDM+OXA-48-like Co-Producing Klebsiella pneumoniae in a Regional Healthcare Network: Seven-Year Surveillance from Latium, Italy
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Overview
Surveillance study describes trends in NDM and OXA-48-like co-producing Klebsiella pneumoniae, highlighting urgent intervention needs.
Key Points
The study aims to characterize the emergence and trends of NDM and OXA-48-like co-producing Klebsiella pneumoniae in a regional network.
Collected CZA-resistant CRE isolates from January 2019 to December 2025 in Latium, Italy.
Performed antimicrobial susceptibility testing, carbapenemase detection, and whole-genome sequencing on NDM-producing K. pneumoniae.
Conducted genomic analyses including multi-locus sequence typing and resistome/virulome profiling.
A total of 2752 CZA-resistant CRE isolates were collected; NDM producers increased from 26.0% in 2024 to 43.6% in 2025.
Whole-genome sequencing revealed ST147 as the dominant clone (63.2%), widely disseminated across 24 hospitals.
Isolates within ST147-KL64 exhibited higher virulence scores, indicating a convergence of resistance and virulence.