Impact of Volatile Organic Compounds on Liver Function in Adolescents: Mediation and Preventive Insights from NHANES

Key Points

• This study investigates the relationship between VOC exposure and liver function in adolescents and explores potential protective mechanisms.
• Analyzed data from NHANES on adolescent liver function and VOC exposure.
• Examined the role of LDH as a mechanism for liver injury due to VOCs.
• Assessed the impact of vitamin D supplementation on liver function.
• Performed statistical analyses to identify associations between VOC exposure and liver health.
• Found a positive association between VOC exposure and impaired liver function in adolescents.
• Identified LDH as a potential mechanism linking VOCs to liver injury.
• Demonstrated that vitamin D supplementation may mitigate the adverse effects of VOC on liver function.