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March 17, 2026European Respiratory Journal0 citations

Within-day test-retest reliability of the timed "up & go" test in patients with advanced chronic organ failure

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RMRafael MesquitaDJDaisy J.A. JanssenEWEmiel F.M. Wouters

Key Result

The Timed "Up & Go" test demonstrated good within-day reliability (ICCs 0.85-0.98) in advanced COPD, CHF, and CRF, with a mean difference of -0.97 s between the first two trials (p<0.05).

Key Points

  • To determine the within-day test-retest reliability of the Timed 'Up & Go' test in patients with advanced COPD, CHF, and CRF.
  • Evaluated 235 patients with advanced chronic organ failure (COPD, CHF, CRF)
  • Conducted three trials of the TUG on the same day
  • Calculated ICC, κ coefficient, SEM, and MDC values
  • Good agreement observed with ICCs ranging from 0.85 to 0.98
  • Statistical improvement from 1st to 2nd trial with mean difference of -0.97 s
  • 3rd trial provided little additional information
  • SEM around 1.6 s and MDC 95% around 4.5 s established for clinical use

Study Design

Type

Observational (n=235)

Structured PICO

Is the Timed 'Up & Go' test reliable for within-day test-retest in patients with advanced chronic organ failure?

P
Population
Patients with advanced chronic organ failure (COPD, CHF, or CRF), median age 70, 64% men
I
Intervention
Timed 'Up & Go' test (TUG) performed in three trials on the same day
O
Outcome
Within-day test-retest reliability (Intraclass Correlation Coefficient, κ coefficient, Standard Error of Measurement, and Minimal Detectable Change)

The Timed 'Up & Go' test demonstrates good within-day test-retest reliability in patients with advanced chronic organ failure after two trials, establishing SEM and MDC values for clinical practice.

Main Result

Effect estimate: Mean difference -0.97 s (95% CI +3.00 to -4.94)

p-value: p=<0.05

Abstract

Background: The Timed "Up BMI 2623-29kg• m -2 ) with advanced COPD (n=95), CHF (n=68), or CRF (n=72) were evaluated. The time to complete the TUG was assessed in three trials performed on the same day. The Intraclass Correlation Coefficient (ICC), κ coefficient, Standard Error of Measurement (SEM), and absolute and relative Minimal Detectable Change (MDC) values were calculated. Results: Good agreement was observed for both the total sample and subgroups (ICCs from 0.85 to 0.98, and κ coefficients from 0.49 to 1.00). However, statistical improvement occurred in the total sample from the 1 st to the 2 nd trial with large limits of agreement (mean difference 95% CI -0.97+3.00 to -4.94 s, p<0.05). The 3 rd trial added little or no information to the first two trials. For the total sample, values of SEM around 1.6 s, MDC 95% around 4.5 s, and MDC 95% % around 35% were found between the first two trials, with close values found for the subgroups. Conclusions: The TUG is reliable in patients with advanced COPD, CHF, or CRF after two trials. Values of SEM and MDC were established and can be used in clinical practice to define what is expected and what represents true change in repeated measures.

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Cite This Study

Mesquita et al. (2013) conducted an observational in Advanced chronic organ failure (COPD, CHF, or CRF) (n=235). Timed "Up & Go" test (TUG) was evaluated on Time to complete the TUG (difference between 1st and 2nd trial) (Mean difference -0.97 s, 95% CI +3.00 to -4.94, p=<0.05). The Timed "Up & Go" test demonstrated good within-day reliability (ICCs 0.85-0.98) in advanced COPD, CHF, and CRF, with a mean difference of -0.97 s between the first two trials (p<0.05).

synapsesocial.com/papers/69b8f10fdeb47d591b8c5e61https://doi.org/10.1183/13993003/erj.42.suppl_57.p1838
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