Why the study?
Does dedicated MRI of carotid plaque composition improve prediction of future stroke or transient ischemic attack compared to measurement of luminal stenosis in patients with carotid atherosclerotic disease?
Does dedicated MRI of carotid plaque composition improve prediction of future stroke or transient ischemic attack compared to measurement of luminal stenosis in patients with carotid atherosclerotic disease?
Dedicated MRI of carotid plaque composition offers valuable stroke risk information beyond standard measurement of luminal stenosis.
May refine stroke risk stratification beyond stenosis; hypothesis-generating pending prospective validation.
The presence of intraplaque hemorrhage, lipid-rich necrotic core, and thinning/rupture of the fibrous cap on MRI of carotid plaque is associated with increased risk of future stroke or transient ischemic attack in patients with carotid atherosclerotic disease. Dedicated MRI of plaque composition offers stroke risk information beyond measurement of luminal stenosis in carotid atherosclerotic disease.
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Gupta et al. (2013) studied this question.
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