The objective of this study was to manufacture gastrointestinal-retentive floating liquid beads made of Metoprolol Succinate (MS). MS is a beta blocker antihypertensive medicine that is metabolized in the liver by first-pass action, which greatly decreases its availability throughout the body. This formulation was made to make the medicine more bioavailable by making it stay in the stomach for up to 12 hours longer. There were 24 different formulas made. These were split into four groups based on the type and amount of polymers utilized, with each group having six formulations. The emulsion gelation technique was employed to create these oil-encapsulated floating medication beads. We looked at a lot of things for each of the formulations we made, such as morphology, floating behavior, drug content, and in vitro % cumulative drug release (%CDR). The physicochemical characteristics of the generated microgel beads were deemed excellent. In vitro testing also showed that each of the prepared batches had good buoyancy. The benchmark was AstraZeneca's Toprol XL 25mg. We used different model-dependent release kinetics, like zero and first order, Higuchi, and Pappas models, to compare the chosen optimal formulation (SF4) with the ordinary marketed formulation. The results showed that the equation of Korsemeyer-Peppa fit the data best for the formulation SF4 (with R2 = 0.9952). This meant that the drug release followed a non-Fickian diffusion process. Keywords: Metoprolol succinate, gastro retentive, FDDS, Sodium alginate, model dependent release kinetics
Vijay et al. (Sun,) studied this question.