What question did this study set out to answer?

To investigate the structural and antimicrobial properties of copper(II) complexes formed with 2,2′-bipyridine and dicyanamide.

March 18, 2026Results in ChemistryOpen Access

Exploring the structural and antimicrobial properties of copper(II) complexes of 2,2′-bipyridine and dicyanamide by X-ray crystallography, DFT calculations and molecular docking studies

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Exploration reveals copper(II) complexes exhibit moderate antimicrobial activity and unique structural characteristics.

To investigate the structural and antimicrobial properties of copper(II) complexes formed with 2,2′-bipyridine and dicyanamide.
Synthesis of two mixed-ligand copper(II) complexes
Characterization through single-crystal X-ray diffraction
Thermal analysis using thermogravimetric methods
Conducting molecular docking studies against bacterial targets
Antimicrobial activity assessment via minimum inhibitory concentration (MIC) tests.
Complex 1 shows distorted trigonal bipyramidal CuN₅ core, while complex 2 exhibits a distorted octahedral CuN₆ environment.
Both complexes have moderate antimicrobial activity with MIC values between 125–1000 μg/mL for complex 2.
Molecular docking indicates strong binding to bacterial DNA gyrase and topoisomerase IV.

Teboh et al. (2026) studied this question.

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