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This research uncovers a novel pathway controlling ferroptosis in kidney disease, suggesting new therapeutic targets for oxalate nephropathy.
We establish the Hippo-YAP1/TEAD1-SLC7A5 axis as a master regulatory pathway controlling oxalate-induced ferroptosis. This pathway represents a promising therapeutic target for oxalate nephropathy and provides fundamental insights into stress-responsive ferroptosis regulation in kidney disease.
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Yang et al. (2026) studied this question.
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