Pentose phosphate pathway in sarcoidosis

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Key Points

To explore the cellular composition and metabolic characteristics in granulomas of sarcoidosis patients.
Single-cell RNA sequencing analysis of granuloma samples from sarcoidosis patients.
Identification of key cell types, particularly TREM2-positive macrophages.
Examination of elevated expression of metabolic enzyme FBP1.
Assessment of pentose phosphate pathway (PPP) activation in macrophages.
Inhibition studies of PPP in vitro and in vivo.
TREM2-positive macrophages play a crucial role in granuloma formation.
FBP1 expression is significantly increased in macrophages within the granulomas.
Activation of the pentose phosphate pathway is observed in FBP1-positive macrophages.
Inhibition of the PPP reduces granuloma formation in both in vitro and in vivo models.

Investigates the role of the pentose phosphate pathway in granuloma formation in sarcoidosis, suggesting new treatment targets.

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Satoshi Nakamizo (2025) studied this question.

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