What question did this study set out to answer?

The study aims to analyze the incidence and causes of severe infections in children undergoing therapy for high-risk neuroblastoma.

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March 18, 2026

Retrospective Analysis of Incidence and Etiology of Severe Infections in Children Receiving Therapy for High‐Risk Neuroblastoma: A Large Single‐Center Experience

Key Points

The study aims to analyze the incidence and causes of severe infections in children undergoing therapy for high-risk neuroblastoma.
Retrospective analysis of data from children receiving therapy for high-risk neuroblastoma.
Assessment of infection incidence and related mortality during treatment.
Evaluation of the types of infections and their potential causes.
Severe infections occurred frequently but had low related mortality rates.
The incidence of invasive fungal diseases was low despite no systematic preventive measures.
Findings provide a benchmark for understanding infection risk in the context of modern immunotherapy and CAR-T treatments.

Abstract

Severe infections remain frequent and clinically significant complications in HR-NB therapy, though infection-related mortality was low. The low incidence of IFDs despite the absence of systematic prophylaxis suggests potential optimization of preventive strategies. These data provide an epidemiologic benchmark for infection risk in the era of immunotherapy and CAR-T approaches for solid tumors.

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