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March 18, 2026The Journal of Sexual Medicine0 citations

Prospective evaluation of testosterone dose strategy in transgender individuals assigned female at birth: hormonal equivalence and psychological and behavioral outcomes

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BKBanu Betul KocamanNBNesibe BoyrazLSLala Soltanova

Key Points

  • To evaluate the effectiveness of half- and full-dose testosterone strategies in transgender individuals assigned female at birth and their psychological outcomes.
  • Prospective evaluation of two testosterone initiation strategies (half-dose and full-dose)
  • Assessment of endocrine and clinical outcomes over 6 months
  • Monitoring of impulsivity as a psychological outcome
  • Half- and full-dose testosterone strategies resulted in comparable early endocrine outcomes
  • Only transient differences in impulsivity were noted
  • Emphasized the need for careful monitoring due to individual variability in responses

Abstract

Half- and full-dose testosterone initiation strategies were associated with comparable early endocrine and clinical outcomes over 6 months, with only transient differences in impulsivity; these findings underscore the importance of careful monitoring during the early treatment phase, given individual variability in behavioral responses.

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Cite This Study

Kocaman et al. (2026) studied this question.

synapsesocial.com/papers/69ba424e4e9516ffd37a2729https://doi.org/10.1093/jsxmed/qdag066
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