β-Boron or β-Silicon Effect Enables a Regioselective Ni-Catalyzed Hydrocyanation of Internal Alkynes

Honggen Wang; Zhi-Hao Chen; Shuang Lin; Xinman Kang; Jiawu Huang; Jiasheng Qian; Qingjiang Li

doi:10.1039/d6gc00727a

January 1, 2026Green Chemistry

β-Boron or β-Silicon Effect Enables a Regioselective Ni-Catalyzed Hydrocyanation of Internal Alkynes

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Key Points

The aim is to improve regioselectivity in the hydrocyanation of internal alkynes using nickel catalysts.
Utilized β-boron or β-silicon as modifying agents in nickel-catalyzed reactions.
Focused on unsymmetric di-alkyl substituted internal alkynes for improved regio-control.
Conducted comparative analysis of reaction outcomes based on different catalysts.
Achieved enhanced regioselectivity in hydrocyanation reactions.
Successfully synthesized a range of alkenyl nitriles with minimal byproducts.
Demonstrated the effectiveness of β-boron and β-silicon modifications in controlling reaction pathways.

Implication

Research demonstrates regioselective hydrocyanation of internal alkynes, suggesting new synthetic pathways.

Abstract

Transition-metal-catalyzed hydrocyanation of alkynes offers a straightforward and atom-economic method to access alkenyl nitriles. However, achieving regio-control remains challenging, especially for unsymmetric di-alkyl substituted inter-nal alkynes. In this study, we...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69ba42bc4e9516ffd37a34e0 https://doi.org/10.1039/d6gc00727a

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β-Boron or β-Silicon Effect Enables a Regioselective Ni-Catalyzed Hydrocyanation of Internal Alkynes

Key Points

Implication

Abstract

Discussion

Cite This Study

β-Boron or β-Silicon Effect Enables a Regioselective Ni-Catalyzed Hydrocyanation of Internal Alkynes

Key Points

Implication

Abstract

Discussion

Cite This Study

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