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March 18, 2026PharmaceuticalsOpen Access

Anti-Inflammatory Activity of Mandragora autumnalis Ethanolic Extract: In Vitro and Cellular Mechanistic Insights

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Authors

GAGhosoon AlbahriHHHeba HellanyABAdnan Badran

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Overview

Evaluates the anti-inflammatory effects of Mandragora autumnalis extract in macrophages, suggesting its potential as a natural treatment option.

Key Points

  • The aim is to investigate the anti-inflammatory properties of Mandragora autumnalis ethanolic extract (MAE) and its underlying mechanisms.
  • Conducted biochemical assays to assess anti-inflammatory activity of MAE
  • Evaluated its effects on LPS-stimulated RAW 264.7 macrophages
  • Measured levels of nitric oxide and pro-inflammatory cytokines
  • Assessed gene and protein expression of inflammatory mediators
  • Investigated activation of key signaling pathways (NF-κB, STAT3, MAPK)
  • MAE inhibited heat-induced protein denaturation and red blood cell hemolysis
  • Significant reduction in nitric oxide production and levels of TNF-α and IL-6 in macrophages
  • Downregulation of iNOS and COX-2 expression observed
  • Inhibition of macrophage migration and inflammatory signaling pathways
  • Molecular docking indicates potential interactions with key inflammatory proteins

Cite This Study

Albahri et al. (2026) studied this question.

synapsesocial.com/papers/69ba42cf4e9516ffd37a366ehttps://doi.org/10.3390/ph19030483
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