What question did this study set out to answer?

The aim is to explore how glycoengineering can improve the effector functions of antibodies by modifying their glycosylation patterns.

March 18, 2026Glycobiology

On the use of glycoengineering methods for the generation of antibodies with enhanced effector functions

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This review explores glycoengineering strategies that enhance antibody effector functions, indicating potential for therapeutic improvements.

The aim is to explore how glycoengineering can improve the effector functions of antibodies by modifying their glycosylation patterns.
Review of glycoengineering strategies applicable to antibody glycosylation.
Analysis of various glycosylation motifs in therapeutic antibodies.
Description of genetic manipulation, metabolic inhibition, and enzymatic remodelling approaches.
Identified key glycosylation motifs that affect antibody binding to Fc-gamma receptors.
Discussed tailored strategies for producing clinically relevant glycoforms.
Summarized current and emerging options for antibody glycosylation modification.

Serafin et al. (2026) studied this question.

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This review explores glycoengineering strategies that enhance antibody effector functions, indicating potential for therapeutic improvements.