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March 18, 2026Nano ResearchOpen Access

A multifunctional antibacterial nanozyme for eradicating multidrug-resistant bacteria and promoting wound repair

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Authors

JCJianjun ChengJZJinghan ZhuJYJiamin Yu

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Overview

Novel nanozymes eliminate multidrug-resistant bacteria and enhance wound healing, highlighting a new therapeutic option.

Key Points

  • This research aims to develop and evaluate a multifunctional nanozyme to combat multidrug-resistant bacterial infections and promote wound repair.
  • Synthesis of gold-copper alloy nanozymes (AuCu₃)
  • In vitro assays against carbapenem-resistant Klebsiella pneumoniae
  • Murine infection models to assess therapeutic efficacy
  • Single-cell RNA sequencing for immunomodulatory pathway analysis
  • AuCu₃ nanozymes showed potent peroxidase-like activity, effectively degrading bacteria in three hours.
  • Demonstrated broad-spectrum antibacterial effects with minimal systemic toxicity.
  • Induced immunometabolic reprogramming in monocytes, shifting metabolism to oxidative phosphorylation.
  • Enhanced innate immune cell recruitment and activated copper homeostasis pathways.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/69ba42fb4e9516ffd37a3c10https://doi.org/10.26599/nr.2026.94908625
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Engineering Nano-Antibiotics for Accelerating Wound Healing in Drug-Resistant Bacterial Infections2026
  2. 2Cu2MoS4 nanozymes reduced bacterial defenses through a dual mechanism to amplify cuproptosis-like death and accelerate the healing of burn-infected wounds2026
  3. 3Metal-Functionalized Nanozymes in Antibacterial Wound Management: Recent Advances and Future Prospectives2026 · 4 citations
  4. 4Light-Activatable Ionic and Photothermal Therapy by CuAu Nanorods for Treating Wounds and Keratitis Caused by Methicillin-Resistant <i>Staphylococcus aureus</i>2024 · 1 citations
  5. 5Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds2026 · 3 citations