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To assess how resolvin D1 affects bronchoconstriction induced by leukotriene D4 and carbachol in isolated rat and human bronchioles.

Effect of resolvin D1 on leukotriene D ₄ -induced constriction of rat and human bronchioles

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To assess how resolvin D1 affects bronchoconstriction induced by leukotriene D4 and carbachol in isolated rat and human bronchioles.
Isolated rat bronchioles were mounted on a wire myograph and exposed to leukotriene D4 and carbachol.
Contractile responses were recorded in the presence or absence of resolvin D1.
Human bronchioles from lobectomy patients were similarly tested.
Leukotriene D4 induced dose-dependent constriction in rat bronchioles, which was abolished by resolvin D1.
Resolvins D1 also inhibited leukotriene D4-induced constriction in human bronchioles.
Carbachol-induced constriction was unaffected by resolvin D1.

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Investigates the effect of resolvin D1 on airway constriction caused by leukotriene D4, indicating potential new treatments for airway diseases.

Jannaway et al. (2013) studied this question.

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Investigates the effect of resolvin D1 on airway constriction caused by leukotriene D4, indicating potential new treatments for airway diseases.