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March 18, 2026Open Access

Cocrystals as a Novel Strategy to Enhance the Solubility and Dissolution Rate of Zolmitriptan: A Comprehensive Review

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Authors

DLDivya Londhe*RCRajshree ChavanDKDr. Prashant Khade

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Overview

This review examines how cocrystals enhance solubility and dissolution rate of zolmitriptan, indicating new opportunities for drug development.

Key Points

  • The review aims to understand how cocrystallization can improve the solubility and dissolution rate of zolmitriptan.
  • Summarizes pharmaceutical cocrystals and their classification.
  • Discusses design strategies and preparation methods for cocrystals.
  • Explores characterization techniques and regulatory considerations.
  • Highlights current challenges and future perspectives of zolmitriptan cocrystals.
  • Cocrystallization can significantly enhance the solubility of zolmitriptan.
  • Improved dissolution rates may lead to faster therapeutic effects.
  • Identifying suitable coformers is crucial for successful cocrystal development.

Cite This Study

Londhe* et al. (2026) studied this question.

synapsesocial.com/papers/69ba42fb4e9516ffd37a3d1fhttps://doi.org/10.5281/zenodo.19049901
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploration of Pharmaceutical Cocrystals of Zaltoprofen: Development, Physicochemical Characterization, and Enhancement of Solubility and Dissolution Behavior2026
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  3. 3FROM COCRYSTAL DESIGN TO DRUG SHELF: NOVEL PREPARATION METHODS AND MARKETED PHARMACEUTICAL PRODUCTS2026
  4. 4Elucidating the Mechanistic Shortcomings of Acetazolamide Cocrystals in Harnessing the Anticipated Solubility and Permeability Advantages2025 · 3 citations
  5. 5Design, Optimization, and Characterization of Zolmitriptan Loaded Liposomal Gels for Intranasal delivery for acute migraine therapy2024 · 7 citations