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March 18, 2026Journal of the Science of Food and Agriculture

Helicobacter pylori infection promotes gastric carcinogenesis by inducing macrophage M2 polarization through the miR ‐146a‐5p/ TRAF6 signaling pathway

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Authors

FJFeng JuYFYe FangJLJiayi Liu

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Overview

Reveals that Helicobacter pylori infection promotes gastric cancer by influencing macrophage polarization.

Key Points

  • To investigate how Helicobacter pylori infection affects macrophage polarization and its role in gastric carcinogenesis.
  • Analyzed macrophage polarization in response to Helicobacter pylori infection.
  • Examined the miR-146a-5p/TRAF6 signaling pathway.
  • Evaluated the effect of polarization on gastric cancer cell function.
  • Helicobacter pylori infection shifted macrophages to the M2 phenotype.
  • M1 polarization was inhibited, affecting the immune response.
  • Enhanced gastric cancer cell function was associated with M2 polarization.

Cite This Study

Ju et al. (2026) studied this question.

synapsesocial.com/papers/69ba43384e9516ffd37a43bbhttps://doi.org/10.1002/jsfa.70581
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  1. 1IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis2024 · 26 citations
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  4. 4Helicobacter pylori and miR-136: Key players in gastric cancer research (mini review)2026
  5. 5M2 macrophages participate in ILC2 activation induced by <i>Helicobacter pylori</i> infection2024 · 25 citations