What does this research mean for the field?

Features representing immune balance, such as the CD8/CD4 ratio and T cell-contextualized metrics, are predictive of pathological response to neoadjuvant chemotherapy in breast cancer, outperforming molecular phenotype alone. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore the relationship between immune cell characteristics and the response to neoadjuvant chemotherapy in breast cancer.

March 18, 2026BiomedicinesOpen Access

A Predictive Immunological Signature Associated with Pathological Response in Breast Cancer Treated with Neoadjuvant Chemotherapy

View Full Paper

Ask AI

Bookmark

Authors

LPLuis Arturo Palafox-MariscalMexican Social Security Institute MGMariel García-ChagollánUniversidad de Guadalajara JGJesús García-GómezUniversidad de Guadalajara

Discussion

Member takes

Implication

Exploratory study identifies immune profile linked to chemotherapy response in breast cancer, suggesting new predictive tools.

Key Points

To explore the relationship between immune cell characteristics and the response to neoadjuvant chemotherapy in breast cancer.
Evaluated immune cell tumor infiltration using next-generation sequencing and automated immunohistochemistry.
Analyzed Tru-Cut biopsies from 57 patients with locally advanced breast cancer.
Determined the frequency of CD4+ and CD8+ T cells and expression of key immune markers.
Utilized image analysis software for detailed examination of immune infiltration.
Cytotoxic tumor microenvironment correlated with sensitivity to chemotherapy.
No significant differences in baseline immune cell abundance across response groups.
Functional organization of the immune environment associated with chemosensitivity.
CD8/CD4 ratio and T cell-contextualized metrics shown as potential predictors of treatment response.

Cite This Study

Palafox-Mariscal et al. (2026) studied this question.

synapsesocial.com/papers/69ba43764e9516ffd37a4af2 https://doi.org/10.3390/biomedicines14030663

View Full Paper

Ask AI

Bookmark

A Predictive Immunological Signature Associated with Pathological Response in Breast Cancer Treated with Neoadjuvant Chemotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

A Predictive Immunological Signature Associated with Pathological Response in Breast Cancer Treated with Neoadjuvant Chemotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider