Glucose 6-phosphate: the diversity of C -methylation in sugar moieties within natural product biosynthesis

Key Points

• The objective is to explore the variability of C-methylation in sugar moieties and its role in natural product biosynthesis.
• Analyzed various sugar units involved in natural product biosynthesis.
• Examined the function of SAM-dependent C-methyltransferases.
• Investigated patterns of methylation diversity.
• Identified multiple sugar moieties subject to C-methylation.
• Demonstrated significant variability in methylation patterns across different sugars.
• Highlights the influence of C-methylation on the biosynthetic pathways of natural products.