Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 18, 2026Diabetes Obesity and Cardiometabolic CARE

Social Determinants of Health and Incident Type 2 Diabetes Risk: Real-World Evidence From the Houston Methodist Cardiovascular Learning Health System Registry

View Full Paper
Ask AI
Bookmark
Share

Authors

ZJZulqarnain JavedJPJerrin PhilipRCRyan Chang

Discussion

Loading...

Member takes

Overview

A retrospective cohort study reveals the significant impact of social determinants on new-onset type 2 diabetes risk, highlighting the importance of addressing these factors.

Key Points

  • To assess the long-term influence of social determinants of health (SDoH) on the risk of new-onset type 2 diabetes mellitus (T2DM).
  • Conducted a retrospective cohort study using data from the Houston Methodist Cardiovascular Learning Health System registry.
  • Analyzed patients aged 18 years or older from 2016-2023.
  • Grouped SDoH factors into a composite index and categorized them into high, low, and optimal risk levels.
  • Used Cox proportional hazards models to analyze the relationship between SDoH burden and incident T2DM.
  • Included 156,677 patients with data on all four SDoH domains.
  • 8% of participants developed new-onset T2DM during a mean follow-up of 3.5 years.
  • A dose-response relationship was observed between SDoH burden and T2DM incidence.
  • Patients with the highest SDoH burden had nearly double the risk of developing T2DM compared to those with optimal social conditions (adjusted hazard ratio 1.95).

Cite This Study

Javed et al. (2026) studied this question.

synapsesocial.com/papers/69ba43984e9516ffd37a4efahttps://doi.org/10.2337/doc25-0006
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11277-OR: Social Determinants of Health Score and Risk of Coronary Heart Disease in a Diverse Cohort of People with Type 2 Diabetes2026
  2. 2Impact of Cumulative Social Determinants of Health on Odds of Diabetes Incidence in US Veterans2026
  3. 3Social Determinants of Health and Cardiovascular Risk among Adults with Diabetes: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study2024 · 7 citations
  4. 4Abstract TH902: Joint Impact of Social Determinants of Health Burden and Coronary Artery Disease on All-Cause and Cardiovascular Mortality: 18-Year Follow-up From National Health And Nutrition Examination Survey 2000–20182026
  5. 5Documentation of social determinants of health for patients with type 2 diabetes in Epic Cosmos2025