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This report aims to highlight the challenges in diagnosing Whipple's disease and its cardiac implications.

March 19, 2026CureusOpen Access

An Uncertain Cardiac Mass: A Case of Whipple’s Disease

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This report aims to highlight the challenges in diagnosing Whipple's disease and its cardiac implications.
Described a case of a 54-year-old man with Whipple's disease and cardiac symptoms.
Utilized echocardiography to identify aortic valve mass and regurgitation.
Performed upper gastrointestinal endoscopy and duodenal biopsies to identify T. whipplei.
Conducted polymerase chain reaction to confirm the presence of T. whipplei in tissues.
Identified a persistent aortic valve mass with regurgitation in the patient.
Confirmed the presence of T. whipplei via polymerase chain reaction from duodenal and excised valve tissue.
Improvement noted after treatment with ceftriaxone, doxycycline, and hydroxychloroquine, alongside aortic valve replacement.

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A case report reveals undiagnosed endocarditis in a patient with Whipple's disease, suggesting the need for careful molecular evaluation.

Fidalgo et al. (2026) studied this question.

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