Immune-mediated pathways between red blood cell traits and prostate cancer: a causal relationship network based on Mendelian randomization evaluation | Synapse
This research investigates the causal links between red blood cell traits and prostate cancer risk, emphasizing immune cell mediation.
Utilized Mendelian randomization to evaluate the relationships between red blood cell traits and prostate cancer risk.
Analyzed traits including red blood cell count, red cell distribution width, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration.
Identified significant associations between specific red blood cell traits and an increased risk of prostate cancer.
Confirmed that immune cells play a critical role in mediating these associations.
Abstract
RBC, RDW, MCH, and MCHC were related to the risk of PCa. Immune cells act as major mediators in this relationship.