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March 19, 2026Journal of Surgical Oncology0 citations

Discordance Between Breast And Nodal Response In Triple-Negative Breast Cancer

Discordance Between Breast and Nodal Pathologic Response in Triple‐Negative Breast Cancer: Methodological Considerations and Contemporary Implications

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Authors

KAKadri Altundag

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Overview

This systematic review reveals discrepancies in breast and nodal pathologic responses, suggesting implications for surgical decisions in triple-negative breast cancer.

Key Points

  • The research aims to explore the differences in breast and nodal pathologic complete response following neoadjuvant chemotherapy for triple-negative breast cancer.
  • Systematic review of cohorts assessing breast and nodal pCR rates post-neoadjuvant chemotherapy
  • Analysis of definitions of pCR across studies, focusing on ypT0, ypT0/is, and ypN0
  • Evaluation of surgical methods ranging from sentinel lymph node biopsy to axillary lymph node dissection
  • Nodal pCR rates were found to exceed breast pCR rates in analyzed cohorts
  • Variability in definitions and baseline staging impacted the perceived discordance between breast and nodal responses
  • Contemporary neoadjuvant regimens, including pembrolizumab, may shift pCR outcomes and response patterns

Cite This Study

Kadri Altundag (2026) studied this question.

synapsesocial.com/papers/69bb928c496e729e6297ff17https://doi.org/10.1002/jso.70241
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