What question did this study set out to answer?

To describe a severe and fatal case of Puumala virus infection presenting atypically with HFRS.

March 19, 2026PathogensOpen Access

A Fatal Case of Puumala Virus Infection with Pulmonary and Renal Syndrome in Moscow Region, Russia

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Clinical manifestations of Puumala virus infection cause sudden death in a patient, suggesting awareness of atypical symptoms is needed.

To describe a severe and fatal case of Puumala virus infection presenting atypically with HFRS.
Analyzed clinical data and autopsy samples from a patient with HFRS.
Conducted genomic sequencing of the Puumala virus strain.
Performed phylogenetic and similarity plot analyses to assess the viral strain characteristics.
Patient exhibited severe symptoms and died within 28 hours of hospitalization.
Genomic sequencing identified the virus strain as endemic to the Moscow region.
Phylogenetic analysis indicated the strain's reassortant origin from M segment exchange.

Blinova et al. (2026) studied this question.

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