Green manufacturing of amoxicillin trihydrate: a malic acid-assisted crystallization framework enhanced by Taguchi–ANN optimization

January 1, 2026RSC AdvancesOpen Access

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Key Points

The aim is to enhance the yield, purity, and crystal quality of amoxicillin trihydrate using an optimized crystallization process.
Utilized malic acid in the crystallization process.
Applied Taguchi optimization techniques combined with artificial neural networks (ANN).
Focused on factors affecting crystallization yield and quality.
Significant improvement in the yield of amoxicillin trihydrate was observed.
Purity levels increased following the optimized crystallization process.
Crystal quality was enhanced under the optimized conditions.

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Demonstrates improved yield and quality of amoxicillin through malic acid-assisted crystallization and optimization techniques.

Malic acid-assisted crystallization combined with Taguchi–ANN optimization improves yield, purity, and crystal quality of amoxicillin trihydrate.

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Ergin et al. (2026) studied this question.

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