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July 29, 2026Chemical PapersOpen Access

Eco-friendly AOP for Amoxicillin removal: hybrid optimization, by-products identification via QUECHERS-HRMS technique, and toxicity assessment

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Authors

MOMouna Imene OusaadiBiotechnology Research CenterMBMohammed BerkaniBiotechnology Research CenterASAnfel SmaaliBadji Mokhtar-Annaba University

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Overview

Randomized trial investigates amoxicillin removal efficiency in aqueous systems, suggesting optimal green methods for detoxification.

Key Points

  • This study aims to optimize the removal of amoxicillin from water using eco-friendly oxidation techniques while assessing toxicity and by-products.
  • Used NaClO/FeSO4 for Fenton-like oxidation; optimized conditions through Response Surface Methodology and modeling.
  • Combined Artificial Neural Networks and Genetic Algorithm for improved prediction and outcomes.
  • Utilized QuEChERS extraction and Direct Infusion-HRMS for by-products analysis and toxicity testing.
  • Achieved 91.8% amoxicillin removal with optimal conditions defined in the study.
  • Predicted and achieved 99% removal under refined conditions with an R2 of 0.991.
  • Ecotoxicity testing showed transient inhibition of Chlorella vulgaris but improved detoxification thereafter.

Cite This Study

Ousaadi et al. (2026) studied this question.

synapsesocial.com/papers/6a69a26dc8da07d9defa5d1fhttps://doi.org/10.1007/s11696-026-05333-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiple response optimization of amoxicillin removal in aqueous solution via ZVI Fenton-like process using factorial design2026
  2. 2Beyond Amoxicillin Removal: Investigating the Antimicrobial and Toxicological Effects of Its Byproducts2025
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