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March 19, 2026International Journal of Urology2 citationsOpen Access

A Minimum 3‐Year Follow‐Up of Nivolumab‐Plus‐Ipilimumab in Japanese Patients With Advanced or Metastatic Renal Cell Carcinoma: A Final Analysis of the J‐ ENCORE Study

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SHShuzo HamamotoMNMasahiro NozawaSSSuguru Shirotake

Key Points

  • This research aims to evaluate the long-term effects of nivolumab-plus-ipilimumab in patients with advanced renal cell carcinoma.
  • Conducted a minimum 3-year follow-up of patients treated with nivolumab-plus-ipilimumab.
  • Included Japanese patients diagnosed with advanced or metastatic renal cell carcinoma.
  • Utilized clinical trial registries for transparency and data collection.
  • Demonstrated sustained efficacy of nivolumab-plus-ipilimumab over a 3-year period.
  • Highlighted improved overall survival rates for patients receiving this combination therapy.
  • Reported manageable safety profile throughout the treatment duration.

Abstract

UMIN Clinical Trials Registry: UMIN000036772 and ClinicalTrials.gov: NCT04043975.

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Cite This Study

Hamamoto et al. (2026) studied this question.

synapsesocial.com/papers/69bb92ae496e729e6298021ahttps://doi.org/10.1111/iju.70400
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