What question did this study set out to answer?

The aim is to develop a method for encapsulating polydeoxyribonucleotides into exosomes to improve skin recovery.

March 19, 2026BMC BiotechnologyOpen Access

A novel method to encapsulate polydeoxyribonucleotides extracted from trout into exosomes and applications in skin recovery

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Demonstrates enhanced skin regeneration using exosome-encapsulated polydeoxyribonucleotides, indicating promising therapeutic applications.

The aim is to develop a method for encapsulating polydeoxyribonucleotides into exosomes to improve skin recovery.
Used electroporation to load fragmented polydeoxyribonucleotides into exosomes.
Extracted and fragmented PDRN to < 200 bp using ultrasound.
Evaluated exosome integrity via nanoparticle tracking and electron microscopy.
Assessed wound healing effects through scratch assays and gene expression analysis.
PDRN-loaded exosomes accelerated wound closure compared to controls.
Reduced levels of pro-inflammatory cytokines were observed in treated samples.
Increased expression of COL1A1 and MMP2 genes at 200 ng PDRN was noted, enhancing extracellular matrix remodeling.

Chang et al. (2026) studied this question.

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Demonstrates enhanced skin regeneration using exosome-encapsulated polydeoxyribonucleotides, indicating promising therapeutic applications.