A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Key Points

• To establish a preclinical mouse model that mimics ovarian cancer-induced depression linked to estrogen deficiency.
• Combined intraperitoneal modeling of ovarian cancer with ovariectomy and chronic stress induction.
• Utilized mice to simulate hypoestrogenic conditions.
• Evaluated behavioral and physiological responses to establish relevance.
• Aimed to create a stable model for future translational research on depression.
• Successfully established a depression model associated with ovarian cancer in mice.
• Demonstrated a clear connection between hypoestrogenic states and depressive behaviors.
• Provided a foundation for studying novel interventions targeting ovarian cancer-related depression.