What question did this study set out to answer?

To illustrate a rare case of tuberculous lymphadenitis presenting with unique hematological and skin manifestations.

March 19, 2026Open Access

Tuberculous lymphadenitis presenting with Coombs-negative hemolytic anemia, vasculitic rash: A rare association

PBPrudvi Tarun BethaIllinois College APAngela Philips

Key Points

To illustrate a rare case of tuberculous lymphadenitis presenting with unique hematological and skin manifestations.
Case report of a 21-year-old male with symptoms including petechiae and swelling.
Clinical evaluation included the direct Coombs test and diagnosing tuberculous lymphadenitis.
Assessment of anemia and skin rash was conducted to establish associations.
Patient presented with scattered petechiae and lower limb swelling, indicating vasculitis.
Direct Coombs test was negative, pointing to Coombs-negative hemolytic anemia.
Diagnosis of tuberculous lymphadenitis was confirmed, guiding treatment approach.

Abstract

Tuberculosis (TB) is a widespread infectious disease that primarily affects the lungs but can manifest in extrapulmonary forms, such as lymphadenitis. The occurrence of severe anemia, direct Coombs test-negative hemolysis, and vasculitic rash in a patient with tuberculous lymphadenitis is an uncommon and challenging clinical scenario. We report the case of a 21-year-old male presenting with scattered petechiae, lower limb swelling, and fatigue, ultimately diagnosed with tuberculous lymphadenitis. This case report highlights the importance of considering TB in atypical presentations to ensure timely diagnosis and treatment.

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