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March 19, 2026The FASEB Journal

Microbiota‐Derived Butyrate Preserves Epithelial Integrity Through SIRT1 ‐Mediated Metabolic‐Epigenetic Crosstalk in Vulvar Lichen Sclerosus

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Authors

YCYuanyuan ChenJPJiajia PanRLRenliang Li

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Overview

Investigation reveals microbial shifts affecting metabolic balance in vulvar lichen sclerosus, suggesting novel therapeutic paths.

Key Points

  • The study aims to understand how gut and reproductive tract microbiota changes affect VLS outcomes.
  • Collected fecal and vaginal samples from 20 VLS patients and 20 healthy women.
  • Analyzed samples at multiple time points using multi-omics profiling.
  • Conducted metabolomic analysis to assess lipid and carbohydrate metabolism changes.
  • Performed in vivo SCFA supplementation in a mouse model to evaluate therapeutic effects.
  • VLS patients showed decreased microbial diversity and altered microbiota composition.
  • There was significant upregulation of inflammatory genes and downregulation of metabolic regulators in VLS.
  • Supplementation with SCFAs restored SIRT1 expression and improved metabolic balance in the mouse model.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69bb92f2496e729e62980a44https://doi.org/10.1096/fj.202502946rr
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