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March 19, 2026Transplantation DirectOpen Access

Transplantation Improves Patient Survival in a PD-first Program in South Africa

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Authors

KMKathryn ManningRFRobert FreercksLivingstone HospitalMDMogamat Razeen DavidsWestern Cape Department of Health

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Implication

Retrospective cohort study reveals improved survival for kidney transplant recipients compared to those on dialysis in South Africa, indicating a need for expanded services.

Key Points

  • This research aims to evaluate the outcomes of kidney replacement therapy allocation and its impact on patient survival, especially focusing on those undergoing transplantation.
  • Retrospective cohort study of patients referred for kidney replacement therapy from 2012 to 2020
  • Cohort followed until death, transplantation, or continued waitlisting as of December 31, 2023
  • Descriptive analyses and comparisons of KRT allocation and outcomes
  • Time-to-event analyses using competing risk models and Kaplan-Meier methods for survival probabilities.
  • 761 patients were referred for kidney failure, with 79% untreated and presumed deceased
  • 48% of presented patients were accepted for dialysis and waitlisted for transplantation
  • Only 21% of those on dialysis were transplanted, showing a clear survival disparity
  • 5-year post-KRT shows a higher probability of dying on the waitlist versus receiving a transplant (35% vs. 18%)
  • Post-transplant survival (100%) significantly outperformed pre-transplant survival (61%).

Cite This Study

Manning et al. (2026) studied this question.

synapsesocial.com/papers/69bb92f2496e729e62980a83https://doi.org/10.1097/txd.0000000000001914
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