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March 19, 2026Cancer Immunology Research

Capturing and tracking clonal T cell response to cancer neoantigens

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Authors

ISIrina A. ShaginaPirogov Russian National Research Medical UniversityTNTatyana O NakonechnayaPirogov Russian National Research Medical UniversityAIAnna V. IzosimovaPrivolzhsky Research Medical University

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Implication

Develops a pipeline to track T cell responses to cancer neoantigens, suggesting new immunotherapy strategies.

Key Points

  • The research aims to develop a method for tracking T cell responses to cancer neoantigens and evaluate its implications for immunotherapy.
  • Developed a cost-efficient wet lab and computational pipeline for identifying mouse TCRs specific to peptides.
  • Produced a dataset of Th TCRβ CDR3s specific to B16 melanoma neoantigens available in VDJdb.
  • Tracked T cell responses to CTLA4 blocking immunotherapy in an orthotopic B16 melanoma model.
  • B16-specific TCR motifs expanded in Th and Treg repertoires of tumor-bearing mice.
  • Stronger expansion noted in Th subsets after CTLA4 blocking treatment.
  • Individual mice showed unique T cell response patterns, indicating diversity in antitumor immunity.

Cite This Study

Shagina et al. (2026) studied this question.

synapsesocial.com/papers/69bb9300496e729e62980d1ehttps://doi.org/10.1158/2326-6066.cir-24-1216
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