Simulated Gastrointestinal Digestion of Cocoa Powder (INFOGEST): Methylxanthine Bioaccessibility, and Antioxidant Properties

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Simulated gastrointestinal digestion of cocoa powder determines the bioaccessibility of its methylxanthines and alters its antioxidant properties. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Leopoldo Rivera-Manzorro; María José Aliaño-González; Gerardo F. Barbero; Nuria Chinchilla Salcedo; Francisco A. Macías; Miguel Palma Lovillo; Ceferino Carrera

doi:10.1039/d5fo05193b

January 1, 2026Food & FunctionOpen Access

Simulated Gastrointestinal Digestion of Cocoa Powder (INFOGEST): Methylxanthine Bioaccessibility, and Antioxidant Properties

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Key Points

This research investigates the bioaccessibility of methylxanthines and antioxidant properties of cocoa powder during simulated digestion.
Conducted simulated gastrointestinal digestion using the INFOGEST protocol.
Analyzed methylxanthines and polyphenols for bioaccessibility during digestion.
Evaluated antioxidant properties using standard assays.
Methylxanthines like theobromine and caffeine showed significant bioaccessibility.
Cocoa powder retained antioxidant properties even after digestion simulation.

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Implication

Experimental analysis reveals methylxanthine bioaccessibility and antioxidant effects of cocoa in gastrointestinal conditions, indicating health benefits.

Abstract

Cocoa (Theobroma cacao L.) is a rich source of bioactive compounds, including methylxanthines (theobromine and caffeine) and polyphenols, which are known for their stimulants, antioxidants, and cardioprotective properties. In this...

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Rivera-Manzorro et al. (2026) studied this question.

synapsesocial.com/papers/69bb9313496e729e62980dc5 https://doi.org/10.1039/d5fo05193b

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Simulated Gastrointestinal Digestion of Cocoa Powder (INFOGEST): Methylxanthine Bioaccessibility, and Antioxidant Properties

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Simulated Gastrointestinal Digestion of Cocoa Powder (INFOGEST): Methylxanthine Bioaccessibility, and Antioxidant Properties

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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