Advances in Exosome‐Based Dermatological and Pharmacological Applications: Analysis of Emerging Topics and Therapeutic Opportunities Using Mapping and Visual Examination

Background Exosomes, small extracellular vesicles, are increasingly pivotal in dermatological research for their therapeutic potential in skin‐related applications. Aim This study provides the first clinically oriented, time‐resolved bibliometric mapping of exosome research in dermatology, integrating thematic evolution, pharmacological relevance, and translational implications from 2001 to 2025. Methods: The study analyzed 810 English‐language original articles from 378 journals, sourced via a structured Scopus search on February 5, 2025, using MeSH‐derived keywords, with analysis conducted using Bibliometrix (R version 4.2.1) and VOSviewer (version 1.6.19) to assess citation patterns, keyword dynamics, and collaborative networks. Results Core journals like International Journal of Molecular Sciences (20 articles) and scholars like Wang, Y. (H‐index = 22) drive the field, with trends toward stem cell–derived exosomes and hydrogels. The field shows a 19.9% annual growth rate and 70.23 citations per document, with exosomes dominating (502 occurrences), followed by wound healing (112), melanoma (56), and angiogenesis (53). Research evolved from wound healing (6 occurrences, 2001–2020) to melanoma and diabetic wound healing (7 each, 2021–2023), and regenerative themes like extracellular vesicles (4, 2024–2025). China leads in output (398 publications) and citations (20,933), while the United States excels in collaboration (TLS = 70). Conclusion Exosomes are central to dermatological innovation, necessitating enhanced global and interdisciplinary collaboration.