What question did this study set out to answer?

This report aims to investigate the effectiveness of lacosamide in treating paroxysmal tonic spasms associated with a new lesion in a patient with multiple sclerosis.

March 19, 2026CureusOpen Access

Lacosamide-Responsive Paroxysmal Tonic Spasms Associated With a New Lateral Cerebral Peduncle Lesion in Multiple Sclerosis: A Case Report

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Authors

MAM'hamed Riad AmanallahCadi Ayyad University HBHamza BenzakourCadi Ayyad University YZYasmina ZakariaCadi Ayyad University

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Implication

A case report shows lacosamide relieves paroxysmal tonic spasms in a woman with multiple sclerosis, indicating its potential in other cases.

Key Points

This report aims to investigate the effectiveness of lacosamide in treating paroxysmal tonic spasms associated with a new lesion in a patient with multiple sclerosis.
Reported a case involving a 31-year-old woman with relapsing-remitting MS
Performed MRI imaging to identify the lesion location
Administered lacosamide after discontinuing carbamazepine due to side effects
Monitored clinical outcomes and symptom resolution
The patient experienced rapid and complete resolution of symptoms after initiating lacosamide
MRI confirmed a new lateral cerebral peduncle lesion consistent with her symptoms
Lacosamide proved to be effective where carbamazepine was not tolerated
Patient remained symptom-free during follow-up, indicating stability

Cite This Study

Amanallah et al. (2026) studied this question.

synapsesocial.com/papers/69bb9345496e729e629814fe https://doi.org/10.7759/cureus.105347

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Implication

A case report shows lacosamide relieves paroxysmal tonic spasms in a woman with multiple sclerosis, indicating its potential in other cases.

Lacosamide-Responsive Paroxysmal Tonic Spasms Associated With a New Lateral Cerebral Peduncle Lesion in Multiple Sclerosis: A Case Report

Discussion

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Implication

Key Points

Cite This Study

Lacosamide-Responsive Paroxysmal Tonic Spasms Associated With a New Lateral Cerebral Peduncle Lesion in Multiple Sclerosis: A Case Report

Discussion

Member takes

Implication

Key Points

Cite This Study

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