What question did this study set out to answer?

The aim is to identify immune cell features that predict early relapse in multiple myeloma after autologous transplantation.

March 19, 2026Blood NeoplasiaOpen Access

CD8+CD38+ T cells Identify Functional High-Risk Multiple Myeloma After Autologous Transplant: BTM CTN 0702 Correlates

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Immunophenotyping identifies CD8+CD38+ T cells as markers of early relapse in multiple myeloma, indicating a high-risk group.

The aim is to identify immune cell features that predict early relapse in multiple myeloma after autologous transplantation.
Conducted immunohistochemistry and flow cytometry on bone marrow and blood samples.
Analyzed CD3+ PD-1+ T cells in a cohort and assessed for markers related to early relapse.
Applied logistic regression for differential expression between early relapse and long-term remission patients.
CD8+CD38+ T cells were identified as key indicators for high-risk multiple myeloma.
The area under the curve (AUC) for risk stratification was 86%.
Differential expression of several markers like HLA-DR and granzyme B distinguished early relapse from long-term remission.

Mehanna et al. (2026) studied this question.

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