Key result
In men with erectile dysfunction, dyslipidemia is linked to ~154% higher odds of LV diastolic dysfunction.
Why the study?
Erectile dysfunction is an early marker of cardiovascular disease, but the specific clinical characteristics associated with cardiac dysfunction remain unclear.
What clinical risk factors are associated with echocardiographic left ventricular systolic and diastolic dysfunction in men with erectile dysfunction?
What clinical risk factors are associated with echocardiographic left ventricular systolic and diastolic dysfunction in men with erectile dysfunction?
Cardiometabolic risk factors, specifically elevated BMI, diastolic blood pressure, HbA1c, and dyslipidemia, are significantly associated with echocardiographic evidence of left ventricular dysfunction in men with erectile dysfunction.
Answers are grounded in this paper and cite their sources.
Supports LV evaluation in men with ED and cardiometabolic risk factors; hypothesis-generating for trials of early risk factor modification to prevent HF.
Background Erectile dysfunction (ED) is recognized as an early marker of cardiovascular disease, but the specific clinical characteristics associated with cardiac dysfunction remain unclear. Aim To identify risk factors for cardiac dysfunction in men with ED as assessed with echocardiography. Methods In this cross-sectional study, men with ED were recruited from a urology outpatient clinic and through invitations to randomly selected men >40 years. Echocardiography was used to assess left ventricular (LV) systolic and diastolic dysfunction. Outcomes Associations between cardiac dysfunction and clinical variables—including age, body mass index (BMI), blood pressure, lipid profile, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein, and cardiovascular comorbidities—were examined. Results Among 398 men, univariable analyses showed that BMI, diastolic blood pressure, and high-sensitivity C-reactive protein were associated with increased odds of LV systolic dysfunction. In multivariable analysis, BMI (OR 1.08; 95% CI: 1.01-1.15), diastolic blood pressure (OR 1.04; 95% CI: 1.01-1.07), and HbA1c (OR 1.06; 95% CI: 1.01-1.12) remained significant. For LV diastolic dysfunction, BMI (OR 1.09; 95% CI: 1.00-1.19) and dyslipidemia (OR 2.54; 95% CI: 1.11-5.72) were associated with LV diastolic dysfunction. Clinical Implications These findings support the importance of cardiovascular risk assessment and targeted prevention strategies in men with ED. Strengths and Limitations A key strength of this study is the large, well-characterized cohort, enabling robust analyses of risk factors for cardiac dysfunction. Its cross-sectional design, however, precludes causal inference. Conclusion Cardiometabolic risk factors are associated with echocardiographic signs of cardiac dysfunction in men with ED. Elevated BMI, diastolic blood pressure, and HbA1c are linked to LV systolic dysfunction, while BMI and dyslipidemia are associated with LV diastolic dysfunction. Clinical Trial Registration The study was prospectively registered at ClinicalTrials.gov (NCT05285280).
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Durukan et al. (2026) studied this question. In men with erectile dysfunction, elevated BMI, diastolic BP, and HbA1c are linked to LV systolic dysfunction, while dyslipidemia (OR 2.54) and BMI are associated with LV diastolic dysfunction.
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