Clozapine Monitoring: Form Follows Function

The elimination of the clozapine risk evaluation and mitigation strategies program provides an opportunity to design a new clozapine monitoring system in which medical monitoring follows a conceptual treatment framework that includes three phases: clozapine trial, treatment optimization, and treatment consolidation. Each phase incorporates reverse medical-psychiatric integration and has distinct treatment goals and monitoring schedules. Each phase begins with a therapeutic decision point when prescribers, patients, and families or legal guardians engage in shared decision making to evaluate treatment options.