Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure

Figures

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  Figure 1. Plasma IL-11 concentrations in control subjects and CHF patients. (a) IL-11 levels in the control, CHF, NYHA II, NYHA III, and NYHA IV groups. N = 80 for the control group, N = 240 for the CHF group, N = 70 for the NYHA II group, N = 76 for the NYHA III group, and N = 94 for the NYHA IV group. (b) Correlation between the NT-pro BNP and IL-11 levels.

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  Figure 2. Comparisons of plasma IL-11 concentrations between the control subjects and HF patients with or without cardiac events. N = 80 for the control group, N = 102 for the CHF with cardiac event-free group, and N = 138 for the CHF with cardiac event group.

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  Figure 3. The diagnostic value of IL-11 in HF and cardiac event. (a) ROC curve of NT-pro BNP and IL-11 for predicting the diagnostic value of HF. (b) ROC curve of IL-11 for predicting the diagnostic value of cardiac event in CHF patients.

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  Figure 4. Hazard ratio of the tertiles of plasma IL-11 concentrations for cardiac events. N = 80 for each group.

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  Figure 5. Kaplan-Meier curve for adverse cardiac events based on low and high plasma IL-11 concentrations. N = 120 for each group. P values are from the log-rank test.