Why the study?
Cardiomyocytes from human induced pluripotent stem cells are functionally immature, limiting their utility.
Does the incorporation of cardiac fibroblasts into 3D microtissues enhance the maturation of hiPSC-derived cardiomyocytes?
Population
hiPSC-derived CMs, CFs, and cardiac endothelial cells
Comparison
hiPSC-MTs with CFs vs MTs without CFs
Design
Preclinical in vitro study
Authors
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May advance hiPSC-CM maturation models via fibroblasts; leaves open clinical translation for cardiomyopathy research.
Does the incorporation of cardiac fibroblasts into 3D microtissues enhance the maturation of hiPSC-derived cardiomyocytes?
Incorporating cardiac fibroblasts into 3D hiPSC-derived cardiac microtissues significantly enhances cardiomyocyte maturation and provides a viable platform for modeling non-cardiomyocyte contributions to diseases like arrhythmogenic cardiomyopathy.
Giacomelli et al. (2020) studied this question.
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