Observational study finds high-risk nonstenotic carotid plaques are linked to stroke recurrence in embolic stroke cases, suggesting clinical relevance.
CTA-based Plaque-RADS can be reliably applied in routine clinical practice to categorize NSCPs in ESUS. Ipsilateral high-risk NSCPs are strongly associated with the index stroke side, lower prevalence of competing cardioembolic sources, and increased ipsilateral recurrence, supporting their role as a distinct causal mechanism within ESUS and underscoring the need for randomized trials on secondary prevention.
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Rizzo et al. (2026) studied this question.
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