Nonstenotic Carotid Plaque in Embolic Stroke of Undetermined Source

Background and Purpose: Approximately one-sixth of all ischemic strokes are attributable to embolic stroke of undetermined source (ESUS). Recent analyses suggest that atrial cardiopathy and nonstenotic carotid plaque (nsCP) may represent 2 distinct underlying causes in patients with ESUS, although both diseases share common risk factors and are pathophysiologically intertwined. In this study, we, therefore, aimed to search for associations between nsCP and markers of atrial remodeling and function in patients with embolic stroke. Methods: Sixty-eight patients with ESUS or atrial fibrillation (AF)-related stroke proven by imaging who underwent comprehensive echocardiographic studies, including measurements of left atrial function and remodeling, were considered. Patients with ESUS underwent a follow-up of at least 1 year after index stroke. For 20 patients with ESUS, NT-proBNP (N-terminal pro-B-type natriuretic peptide) values were available. Presence of nsCP was evaluated considering Duplex sonography and computed tomography angiography and was further categorized in possibly or probably symptomatic nsCP. Results: ESUS patients with nsCP tended to have higher values of septal and lateral total atrial conduction times ( P =0.071 and P =0.072, respectively), left atrial volume index ( P =0.077), and revealed significantly higher strain rates during early diastole ( P =0.013) as well as higher NT-proBNP values ( P =0.010) than ESUS patients without nsCP. Moreover, septal total atrial conduction time was significantly longer in ESUS patients with possibly symptomatic nsCP compared with those without ( P =0.015). Comparison of ESUS with AF patients revealed significantly higher proportions of nsCP ( P =0.010), possibly symptomatic nsCP ( P =0.037), and probably symptomatic nsCP ( P =0.036) in patients with atrial fibrillation-related stroke. In the regression analysis adjusted for vascular risk factors probably symptomatic nsCP remained significantly associated with AF ( P =0.048, odds ratio: 4.46 [95% CI, 1.02–19.56]). Conclusions: Presence of nsCP is associated with AF and markers of left atrial disease in patients with embolic stroke. Therefore, a thorough evaluation regarding atrial cardiopathy and AF in patients with ESUS should not be restricted if nsCP are found, even if high-risk plaque characteristics are evident.