Key result
Increasing left atrial dimension is not linked to ipsilateral cervical plaque in ESUS patients.
Why the study?
The relationship between atrial cardiopathy and atherosclerotic plaque among patients with embolic stroke of undetermined source remains unclear.
Population
3983 patients with recent ESUS enrolled in the NAVIGATE ESUS trial
Comparison
Association between atrial cardiopathy markers and cervical plaque ipsilateral to brain infarction
Design
Post hoc cross-sectional analysis of a clinical trial
Authors
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Supports distinct atrial cardiopathy and plaque pathways in ESUS; leaves open mechanism-specific prevention trials.
Observational (n=3,983)
Yes
Odds Ratio: 1.1 (95% CI 1–1.2)
p-value: p=0.08
Atrial cardiopathy and atherosclerotic plaque appear to be distinct, nonoverlapping risk factors for stroke among patients with embolic stroke of undetermined source.
Kamel et al. (2020) conducted an observational in Embolic stroke of undetermined source (ESUS) (n=3,983). Atrial cardiopathy (increasing left atrial dimension) was evaluated on Cervical plaque ipsilateral to brain infarction (OR 1.1, 95% CI 1.0-1.2, p=0.08). Increasing left atrial dimension was not significantly associated with ipsilateral cervical plaque among patients with embolic stroke of undetermined source (OR per cm 1.1; 95% CI 1.0-1.2; P=0.08).
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