Hierarchical ventilator-free days with win method in acute respiratory distress syndrome treatment

Key Points

• The research aims to enhance the sensitivity and interpretation of treatment effects in ARDS using hierarchical ventilator-free days as an endpoint.
• Analyzed hierarchical ventilator-free days (VFDs) using win statistics.
• Compared contributions of mortality and ventilation duration components to overall treatment effects.
• Utilized ARDS trial data to assess conventional vs. novel approaches.
• Hierarchical VFDs offered more sensitivity than conventional approaches.
• The win method provides clearer interpretations of treatment effects.
• Distinct contributions from mortality and ventilation duration were identified.