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Population pharmacokinetic modeling demonstrates saliva can estimate plasma levels in multidrug-resistant tuberculosis, suggesting a simpler monitoring method.
The validated model enables reliable estimation of plasma AUC₀₋₂₄ using limited saliva samples. A single saliva sample (pre-dose or 2 h post-dose) can accurately predict plasma AUC₀₋₂₄, supporting saliva-based TDM as a practical alternative to plasma-based monitoring of linezolid in MDR-TB.
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Nguyễn et al. (2026) studied this question.
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